Basic Information
VIS ID
TVIS20004544
Fusion event
HPV-SUPT20HL2 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E2
Start
3413
Integrated sequence
AAAGATGATGCAGAAAAATATAG TAAAAATAAAGTATGGGAAGTTCATGCGGGTGGTCAGGTAATATTATGTCCTACATCTGTGTTTAGCAGC AACGA| |AGTATCCTCTCCTGAAATTATTAGGCAGCACTTGGCCAACCACCCCGCCGCGACCCATACCAAAG CCGTCGCCTTGGGCACCGAAGAAACACAGACGAC
Host Sequence
Chromosome
chrX
Cytoband
p22.11
Reference genome
GRCh37/hg19
Start
24333382/24315265 (Hg38)
End
24333382/24315265 (Hg38)
Location type
Intronic
Target gene
SUPT20HL2
Nearest miRNA
hsa-mir-23c/Upstream/4298078; hsa-let-7f-2/Downstream/4180290;
Nearest TSS
ENST00000429181/Upstream/142509; ENST00000493226/Downstream/149956;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1035, chrX-CpG: 31/Downstream/46923
Upstream sequence
TTCTTTAGAGTGGAAAAATATTTTATGAAGCATTGTGTTTCTGAATATGAATTCAATTCAATTCTGTTATCGGGCCTTCCTTAAAATGATTCAAACATTC
Downstream sequence
aatgaaagatgtattcctgagcacgagcagctccgaacaacgggtccacgctggggaccttggaagacagtacagaataagcctcagattgttcttccct
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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