hsa-mir-3654 _CESC.png
DCAF12L2 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004546
Fusion event
HPV-DCAF12L2 integration
Validated
Yes
Detection method
Multiplex RT-PCR, APOT assay
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Normal
Reported year
2014
PubMed ID
23824673
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
K02718
Gene
E1
Start
1529
Integrated sequence
AGACACACTATATGCCAAACACCACTTACAAATATTTTAAATGTACTAAAAACTAGTAATG CAAAGGCAGCAATGTTAGCAAAATTTAAAGAGTTATAC| |GGGGTGAGTTTTTCAGAATTAGTAAGACCATT TAAAAGTAATAAATCAACGTGTTGCGATTGGTGTATTGCTGCATTTGGACTTACACCCAGTATAGCT
Host Sequence
Chromosome
chrX
Cytoband
q25
Reference genome
GRCh37/hg19
Start
124850317/125716329 (Hg38)
End
124850317/125716329 (Hg38)
Location type
Intronic
Target gene
DCAF12L2
miRNAs that regulate target gene
hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-101-3p ; hsa-mir-4716-5p ; hsa-mir-7151-5p ; hsa-mir-1243 ; hsa-mir-3654 ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-144-3p
Nearest miRNA
hsa-let-7f-2/Upstream/4345276; hsa-mir-105-1/Downstream/8453049;
Nearest TSS
ENST00000429181/Upstream/396209; ENST00000438994/Downstream/393433;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/396028, chrX-CpG: 104/Downstream/448933
Upstream sequence
atgtccaagaacaggagaagtgtctcccagctccacaagagaaagattatgcaaattcatttgcctttctctgttttttcttctatccgggcctacagat
Downstream sequence
gtggatttcttgtcagaaacgtggacaccaaagaaaaggggcataaaatttttcaaactgctagaagaaaaaaactttcagatagaattccatctttcag
Reference
Lu, X., et al. Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical cancer. PLoS One ,2014,9(7): e97588.
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