MDGA2 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004554
Fusion event
HPV-MDGA2 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E6
Start
450
End
474
Integrated sequence
AAGACATCTGGACAAAAAGCAAAGA
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
47984368/47515165 (Hg38)
End
47984397/47515194 (Hg38)
Location type
Intronic
Target gene
MDGA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-153-5p ; hsa-mir-1250-3p
Nearest miRNA
hsa-mir-208a/Upstream/10562774; hsa-mir-1185-1/Downstream/245801;
Nearest TSS
ENST00000550708/Upstream/171931; ENST00000557531/Downstream/111331;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/863209, chr14-CpG: 186/Downstream/159036
Downstream sequence
AGTGCTCCTAGACTTGCACAGCAGACTAG
Target sequence
GTGACTCCTAGACTTGCACAGCAGACTAG
Junction sequence
AAAGACATCTGGACAAAAAGCAAAGTGCTCCTAGACTTGCACAGCAGACTAG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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