Basic Information
VIS ID
TVIS20004555
Fusion event
HPV-chr20:p11.1 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E6
Start
469
End
495
Integrated sequence
CAAAGATTCCATAATATAAGGGGTCGG
Host Sequence
Chromosome
chr20
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
26257343/26276707 (Hg38)
End
26257366/26276730 (Hg38)
Nearest miRNA
hsa-mir-103a-2/Upstream/68429; hsa-mir-1-1/Downstream/5330456;
Nearest TSS
ENST00000382410/Upstream/88269; ENST00000400552/Downstream/4011749;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/66995, chr20-CpG: 81/Downstream/2325629
Downstream sequence
CCCATGGTATCGATCTGTGCTGCA
Target sequence
ccatggtatcgatctgtgctgca
Junction sequence
GCAAAGATTCCATAATATAAGGGGTCGAGGCCCATGGTATCGATCTGTGCTGCA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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