Basic Information
VIS ID
TVIS20004557
Fusion event
HPV-chr7:p11.2 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E7
Start
685
End
719
Integrated sequence
CTGGACAAGCAGAACCGGACAGAGCCCATTACAAT
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
54144011/54076318 (Hg38)
End
54144039/54076346 (Hg38)
Fragile sites / regions
FRA7A
Nearest miRNA
hsa-mir-1183/Upstream/9194518; hsa-mir-10399/Downstream/2879439;
Nearest TSS
ENST00000635602/Upstream/128574; ENST00000629899/Downstream/124878;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/856819, chr7-CpG: 48/Downstream/465695
Downstream sequence
GCTACTGCTTGTGCTATAATTGCTAGAGT
Target sequence
CTACTGCTTGTGCTATAATTGCTAGAGT
Junction sequence
GCTGGACAAGCAGAACCGGACAGAGCCCATTACAAGCTACTGCTTGTGCTATAATTGCTAGAGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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