Basic Information
VIS ID
TVIS20004569
Fusion event
HPV-ALG1L5P integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E2
Start
3199
End
3226
Integrated sequence
AGGGTCAAGTTGACTATTATGGTTTATA
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
6964845/6925188 (Hg38)
End
6964819/6925214 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
ALG1L5P
Nearest miRNA
hsa-mir-339/Upstream/1213278; hsa-mir-10399/Downstream/141750;
Nearest TSS
ENST00000635602/Upstream/98418; ENST00000467716/Downstream/231720;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/69274, chr7-CpG: 16/Downstream/9912
Upstream sequence
CCTGGAGGAGGCATTTCAGCCTGAGGG
Target sequence
CCTCAGGCTGAAATGCCTCCTCCAGG
Junction sequence
CCTGGAGGAGGCATTTCAGCCTGAGGGTCAAGTTGACTATTATGGTTTAT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
Curate