Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene2714815327042364270706222709888927119115270690342708395327086747271007722707856727086408271237892713081227090630270972002708508227089890271307562713467527049448270526892713261727135632271368482713941027117439271195712706234127064322270556122705738827122818271245122707047227071773270536182705427627049683270502642706242827062907270839612708418627059573270597222709871327098862271110922711115127139400271394592709524527095272
KHK _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004576
Fusion event
HPV-KHK integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
L2
Start
4940
End
4962
Integrated sequence
AAAGTTGTAGACCCTGCTTTTGT
Host Sequence
Chromosome
chr2
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
27318140/27095245 (Hg38)
End
27318113/27095272 (Hg38)
Location type
Intronic
Target gene
KHK
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1301/Upstream/1766524; hsa-mir-10b/Downstream/901095;
Nearest TSS
ENST00000437798/Upstream/580; ENST00000622011/Downstream/6878;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/8343, chr2-CpG: 78/Downstream/23427
Upstream sequence
AGAACAGTTTCCCCGCACCCACAGCCAA
Target sequence
TGGCTGTGGGTGCGGGGAAACTGTTCT
Junction sequence
AGAACAGTTTCCCCGCACCCACAGCCAAATAAAGTTGTAGACCCTGCTTTTG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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