MIOS _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004578
Fusion event
HPV-MIOS integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
L2
Start
5437
End
5464
Integrated sequence
TTTTGGTGGTGCATACAATATTCCTTTA
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
7628821/7589190 (Hg38)
End
7628904/7589273 (Hg38)
Location type
Intronic
Target gene
MIOS
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-339/Upstream/522145; hsa-mir-10399/Downstream/10537947;
Nearest TSS
ENST00000635602/Upstream/6236; ENST00000479694/Downstream/15845;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/21798, chr7-CpG: 69/Downstream/50936
Target sequence
AATAAATGCCTTTTTAAAATATTTTAAATGATTATGGATATTGCTTTGAAATTTGTAATAGATGCAGACTTCTTAGTTAAATA
Junction sequence
CTTTTGGTGGTGCATACAATATTCCTTTTAATATTCCTTTTAATAAATGCCTTTTTAAAATATTTTAAATGATTATGGATATTGCTTTGAAATTTGTAATAGATGCAGACTTCTTAGTTAAATA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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