STXBP6 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004585
Fusion event
HPV-STXBP6 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Cell line
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Region type
LCR
Start
7219
End
7256
Integrated sequence
TTGTAAATATTAAGTTGTATGTGTGTTTGTATGTATGG
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
25288208/24818974 (Hg38)
End
25288180/24819002 (Hg38)
Location type
Intronic
Target gene
STXBP6
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-4539
Nearest miRNA
hsa-mir-208a/Upstream/675409; hsa-mir-1185-1/Downstream/2089640;
Nearest TSS
ENST00000550708/Upstream/184707; ENST00000547786/Downstream/475;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/388802, chr14-CpG: 125/Downstream/230216
Upstream sequence
GGGTGTTGGGGAGCTACAGTGCCAAGAAA
Target sequence
TTCTTGGCACTGTAGCTCCCCAACACCC
Junction sequence
GGGTGTTGGGGAGCTACAGTGCCAAGAAAATACTTGTAAATATTAAGTTGTATGTGTGTTTGTATGTATG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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