DIAPH2 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004590
Fusion event
HPV-DIAPH2 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E1
Start
1361
End
1400
Integrated sequence
GGTTGCAGTCAGTACAGTAGTGGAAGTGGGGGAGAGGGTG
Host Sequence
Chromosome
chrX
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
96380863/97125864 (Hg38)
End
96380894/97125895 (Hg38)
Location type
Intronic
Target gene
DIAPH2
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-let-7f-2/Upstream/2062638; hsa-mir-105-1/Downstream/9513919;
Nearest TSS
ENST00000429181/Upstream/241956; ENST00000627700/Downstream/438610;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/440497, chrX-CpG: 23/Downstream/2813441
Upstream sequence
TTAACAAAAATACATTTTTTTTGTTCTTGATG
Target sequence
TAACAAAAATACATTTTTTTTGTTCTTGATG
Junction sequence
TTAACAAAAATACATTTTTTTTGTTCTTGATGGTTGTAGTCAGTACAGTAGTGGAAGTGGGGGAGAGGGT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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