hsa-mir-21-5p _CESC.png
TP63 _CESC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS20004599
Fusion event
HPV-TP63 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E5
Start
3858
End
3901
Integrated sequence
TTGATACTGCATCCACAACATTACTGGCGTGCTTTTTGCTTTGC
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
189597479/189879690 (Hg38)
End
189597513/189879724 (Hg38)
Location type
Intronic
Target gene
TP63
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-92a-3p ; hsa-mir-21-5p ; hsa-mir-124-3p ; hsa-mir-301b-3p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-4477b ; hsa-mir-1178-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428
Nearest miRNA
hsa-let-7g/Upstream/49681; hsa-mir-3137/Downstream/5254782;
Nearest TSS
ENST00000440867/Upstream/89889; ENST00000412203/Downstream/84397;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/931927, chr3-CpG: 99/Downstream/240567
Nearest cancer related gene
TP63(TSG, No orient, 0)
Downstream sequence
CTTGATCTACCTTATCTCAGTGGTCCTCGACTGAA
Target sequence
ttgatctaccttatctcagtggtcctcGACTGAA
Junction sequence
CTTGATACTGCATCCACAACATTACTGGCGTGCTTTTTGCTTTGCTTGATCTACCTTATCTCAGTGGTCCTCGACTGAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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