Basic Information
VIS ID
TVIS20004600
Fusion event
HPV-chr3:q28 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E5
Start
3955
End
3977
Integrated sequence
GTCTACATACACATCATTAATAA
Host Sequence
Chromosome
chr3
Cytoband
q28
Reference genome
GRCh37/hg19
Start
189620958/189903169 (Hg38)
End
189620988/189903199 (Hg38)
Nearest miRNA
hsa-let-7g/Upstream/73160; hsa-mir-3137/Downstream/5231307;
Nearest TSS
ENST00000440867/Upstream/113368; ENST00000412203/Downstream/60922;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/955406, chr3-CpG: 99/Downstream/217092
Nearby gene
TP63(-5890) ;
Nearest cancer related gene
TP63(TSG, -5890) ;
Upstream sequence
aaagaagaaccaggtgatccagacttccctT
Target sequence
aagaagaaccaggtgatccagacttccCTT
Junction sequence
aaagaagaaccaggtgatccagacttccctTGTCTACATACACATCATTAATA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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