Basic Information
VIS ID
TVIS20004611
Fusion event
HPV-chr6:p21.2 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E1
Start
1464
End
1482
Integrated sequence
GTAATGCAAAGGCAGCAAT
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
37143517/37175741 (Hg38)
End
37143550/37175774 (Hg38)
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/553229; hsa-mir-10398/Downstream/379591;
Nearest TSS
ENST00000381078/Upstream/3247; ENST00000373491/Downstream/42715;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/4083, chr6-CpG: 29/Downstream/81808
Nearby gene
PIM1(-313) ;
Nearest cancer related gene
PIM1(OG, -313) ;
Upstream sequence
TGGCCACCTCATATAAAACATCATTGCAGAAAGT
Target sequence
ggccacctcatataaaacatcattgcagaaagt
Junction sequence
TGGCCACCTCATATAAAACATCATTGCAGAAAGTAATGCAAAGGCAGCAA
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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