Basic Information
VIS ID
TVIS20004625
Fusion event
HPV-chr6:p22.1 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
L2
Start
5255
End
5278
Integrated sequence
TTACAAACTATAACACCTTCTACA
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
37164521/37196745 (Hg38)
End
37164552/37196776 (Hg38)
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/574233; hsa-mir-10398/Downstream/358589;
Nearest TSS
ENST00000381078/Upstream/24251; ENST00000373491/Downstream/21713;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/25087, chr6-CpG: 29/Downstream/60806
Upstream sequence
CTCTGCCTCCCAGGTTCGAACAATTCTCCTAT
Target sequence
tctgcctcccaggttcaaacaattctcctat
Junction sequence
CTCTGCCTCCCAGGTTCGAACAATTCTCCTATTACAAACTATAACACCTTCTAC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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