Basic Information
VIS ID
TVIS20004629
Fusion event
HPV-chr6:p21.2 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
L1
Start
6410
End
6440
Integrated sequence
ACATTTATTTAATAGGGCTGGTACTGTTGGT
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
36904431/36936655 (Hg38)
End
36904461/36936685 (Hg38)
Fragile sites / regions
FRA6H
Nearest miRNA
hsa-mir-1236/Upstream/314143; hsa-mir-10398/Downstream/618680;
Nearest TSS
ENST00000381078/Upstream/50791; ENST00000491324/Downstream/7990;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/50504, chr6-CpG: 35/Downstream/22467
Nearby gene
C6orf89(-7691) ;
Upstream sequence
AAACACAGCACTAATCTAAAAACCAACTTGA
Target sequence
AACACAGCACTAATCTAAAAACCAACTTGA
Junction sequence
AAACACAGCACTAATCTAAAAACCAACTTGACATTTATTTAATAGGGCTGGTGCTGTTGG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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