Basic Information
VIS ID
TVIS20004630
Fusion event
HPV-chr2:q23.3 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
L1
Start
6589
End
6627
Integrated sequence
GCCACAATAATGGCATTTGTTGGGGTAACCAACTATTTG
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
151992545/151136031 (Hg38)
End
151992576/151136062 (Hg38)
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-128-1/Upstream/1805658; hsa-mir-10b/Downstream/232272;
Nearest TSS
ENST00000437798/Upstream/87257; ENST00000460812/Downstream/50147;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/649354, chr2-CpG: 56/Downstream/125307
Upstream sequence
TTTCCACCATGAAAATCCTTCTTTCAGCACTG
Target sequence
ttccaccatgaaaatccttctttcagcactg
Junction sequence
TTTCCACCATGAAAATCCTTCTTTCAGCACTGGCCACAATAATGGCATTTGTTGGGGTAACCAACTATTT
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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