Basic Information
VIS ID
TVIS20004642
Fusion event
HPV-chr11:q13.4 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Gene
E6
Start
505
End
531
Integrated sequence
CGATGTATGTCTTGTTGCAGATCATCA
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
71162944/71451898 (Hg38)
End
71162968/71451922 (Hg38)
Fragile sites / regions
FRA11H
Nearest miRNA
hsa-mir-10392/Upstream/579530; hsa-let-7a-2/Downstream/21581;
Nearest TSS
ENST00000527297/Upstream/3224; ENST00000533612/Downstream/946;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/3113, chr11-CpG: 51/Downstream/1129
Nearby gene
DHCR7(-3467) ; NADSYN1(+1273) ;
Upstream sequence
GGGTCATATATTACATGCTTTGCTC
Target sequence
ggtcatatattacatgctttgctc
Junction sequence
GGGTCATATATTACATGCTTTGCTCGATGTATGTCTTGTTGCAGATCATC
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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