Basic Information
VIS ID
TVIS20004651
Fusion event
HPV-LOC102724122 integration
Validated
Yes
Detection method
FISH, WGS, RNA-seq, qPCR
Data source
Curated
Sample type
Tumor
Disease
Cervical carcinoma (CC)
Quality evaluation
Perfect
Reported year
2014
PubMed ID
24201445
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
NC_001357.1
Gene
L2
Start
4225
End
4255
Integrated sequence
TATTTTTGTAATAAAAGTATGGTATCCCACC
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
56830246/57534396 (Hg38)
End
56830223/57534419 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
LOC102724122
Nearest miRNA
hsa-mir-10397/Upstream/2025470; hsa-mir-103a-1/Downstream/995624;
Nearest TSS
ENST00000502646/Upstream/51587; ENST00000513392/Downstream/39608;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/359702, chr5-CpG: 157/Downstream/925088
Downstream sequence
ACATTACTAGTCATCAGGGCAATG
Target sequence
attgccctgatgactagtaatgt
Junction sequence
GTATTTTTGTAATAAAATTATGGTATCCCACAAAATACATTACTAGTCATCAGGGCAATG
* Color:  Human Sequence / Virus Sequence / Overlapped sequence / Unknown sequence
Reference
Akagi, K., et al.Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability. Genome Res ,2014,24(2): 185-199.
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