Basic Information
VIS ID
TVIS20005052
Fusion event
HPV-MANCR integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV45
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
4638986/4596794 (Hg38)
End
4788970/4746778 (Hg38)
Location type
Intronic
Target gene
MANCR
Nearest miRNA
hsa-mir-5699/Upstream/605535; hsa-mir-107/Downstream/1405418;
Nearest TSS
ENST00000439456/Upstream/170615; ENST00000525627/Downstream/39851;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/810860, chr10-CpG: 60/Downstream/79155
Nearby gene
KLF6 ; AKR1E2(+) ;
Upstream sequence
atgatgaatgatctttttaatgtgttgctgaattctgtttgctagtattttgtggaagacttttttttttatcaatgttcatcagatatatttgcctata
Downstream sequence
CTTAAATATATGTTTAATGTCAAATATATGTATATATTTTAAGAATAATATTTGTTACTCAAATTATTTTTCTTGAATTACATAGAATATTTCTTCAAAA
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate