Basic Information
VIS ID
TVIS20005062
Fusion event
HPV-CASC8 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Neuroendocrine carcinoma (NC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128302012/127289767 (Hg38)
End
128314759/127302514 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
CASC8
Nearest miRNA
hsa-mir-12123/Upstream/2467709; hsa-mir-10400/Downstream/493448;
Nearest TSS
ENST00000518652/Upstream/45130; ENST00000644588/Downstream/19669;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/731242, chr8-CpG: 29/Downstream/13128
Nearby gene
CCAT1 ; POU5F1B(+) ;
Upstream sequence
ttctaggtatttacccaaaagaaatgaaaatatagccacgggctgaaagctggaaacaacctagacacccaataacagctgaatagacaaacagattgtg
Downstream sequence
TGACCCCACTCGCCTGCCATCTACCCATAGCAGCTTGCATTACAGAGAGAGGCAGagtttacaaaggcctctgcacgcatcatcccatttgattcccaca
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate