Basic Information
VIS ID
TVIS20005065
Fusion event
HPV-RAD51B integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Adenosquamous carcinoma (ASC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68592064/68125347 (Hg38)
End
68667626/68200909 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/683417; hsa-mir-1185-1/Downstream/4315911;
Nearest TSS
ENST00000550708/Upstream/125068; ENST00000554575/Downstream/186228;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/450182, chr14-CpG: 40/Downstream/427389
Nearby gene
ZFYVE26 ; ZFP36L1(+) ;
Upstream sequence
ATGTCAGAAATAATTACTTCCTTACTCTCCTTTTATTTGTGACATTAATTATTTGGAGAAATTGGATATCAAATGCCCTATATTCTAGATTTGGCTGATG
Downstream sequence
ggtctcccaaagtgggattacaggtgtaagctaccatgcccATCCACATGGTTTTTTCTATAATTGTACAAAGGCAGCAGCTGGATCCCCAGAAGCTACT
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate