Basic Information
VIS ID
TVIS20005067
Fusion event
HPV-GLI2 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
HQ644271.1
Host Sequence
Chromosome
chr2
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
121604585/120847010 (Hg38)
End
121757551/120999975 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
GLI2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-218-5p ; hsa-mir-574-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-6819-5p ; hsa-mir-6812-5p ; hsa-mir-6737-5p ; hsa-mir-6740-5p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-4748 ; hsa-mir-4464 ; hsa-mir-466 ; hsa-mir-6793-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-95-5p ; hsa-mir-223-5p ; hsa-mir-541-3p ; hsa-mir-654-5p ; hsa-mir-6769a-5p ; hsa-mir-6769b-5p ; hsa-mir-92a-2-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/7125642; hsa-mir-10b/Downstream/6423562;
Nearest TSS
ENST00000437798/Upstream/49665; ENST00000432984/Downstream/88751;
Nearest CpG islands
chr2-CpG: 23/Target, None/Upstream, None/Downstream
Nearby gene
INHBB ; TFCP2L1(+) ;
Nearest cancer related gene
GLI2(OG, No orient, 0)
Upstream sequence
TTACCCAAAAAATGTAAACTAAGATTCAGTGTTCTTGGTGATTTCTTTTCTCTTCTCTCTTTCTTACAATCTTGTTTTCACCTTTTCTTTTGGCAGGAGA
Downstream sequence
ccttggcttcagaaagacattcataccaccaaggccagaagcaacaagcactgacagctctcagtctgtcctcgtgggctccagcttgtccttgctcccc
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate