VISDB Viral Integration Site DataBase

VIS ID

TVIS20005068

Fusion event

HPV-CEACAM5 integration

Validated

Yes

Detection method

RNA-Seq+RT-PCR

Data source

Curated

Sample type

Disease

Adenocarcinoma (AC)

Quality evaluation

Good

Reported year

2014

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Chromosome

chr19

Cytoband

q13.2

Reference genome

Start

End

42233185/41729265 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-4279 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-4783-5p ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-764 ; hsa-mir-552-3p ; hsa-mir-582-3p

Nearest miRNA

hsa-mir-10395/Upstream/1350910; hsa-let-7e/Downstream/140362;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/76555, chr19-CpG: 51/Downstream/115347

Nearby gene

CEACAM7 ; CEACAM6(+) ;

Upstream sequence

GGAGCTGGTTTCACCCCgtgtttgttttctatggccgccgtcaacaaatgacacagccttggtggctgaaacaacacaagtgattttcgtacagtcctgg

Downstream sequence

gactctgaccagagatcgagaccatcctagccaacatcgtgaaaccccatctctactaaaaatacaaaaatgagctgggcttggtggcgcgcacctgtag

Target sequence

CAGGATTGGGACAGGATTCAGAGGGACACTGTGGCCCTTCTACAATCAGGAGCTTCCCCTTTCCTCTGATGACATCACCTGTGGCTTTGTTCTCTTTGTTCCAGATGGGCCGGACACCCCCATCATTTCCCCCCCAGACTCGTCTTACCTTTCGGGAGCGAACCTCAACCTCTCCTGCCACTCGGCCTCTAACCCATCCCCGCAGTATTCTTGGCGTATCAATGGGATACCGCAGCAACACACACAAGTTCTCTT