VISDB Viral Integration Site DataBase

VIS ID

TVIS20005075

Fusion event

HPV-chr17:q12 integration

Validated

Yes

Detection method

RNA-Seq+RT-PCR

Data source

Curated

Sample type

Disease

Squamous-cell carcinoma (SCC)

Quality evaluation

Good

Reported year

2014

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Chromosome

chr17

Cytoband

q12

Reference genome

Start

End

37921347/39765094 (Hg38)

Location type

Intronic

Target gene

ERBB2 ; GRB7 ; IKZF3 ; MIEN1 ; PGAP3 ; PNMT ; STARD3 ; TCAP

miRNAs that regulate target gene

hsa-mir-559 ; hsa-mir-548d-3p ; hsa-mir-125b-5p ; hsa-mir-21-5p ; hsa-mir-125a-5p ; hsa-mir-331-3p ; hsa-mir-205-5p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-26b-5p ; hsa-mir-326 ; hsa-mir-221-3p ; hsa-let-7b-5p ; hsa-mir-375 ; hsa-mir-25-3p ; hsa-mir-125b-5p ; hsa-mir-670-3p ; hsa-mir-4326 ; hsa-mir-552-3p ; hsa-mir-541-3p ; hsa-mir-498 ; hsa-mir-323b-5p ; hsa-mir-193a-5p ; hsa-mir-193a-3p ; hsa-mir-134-5p ; hsa-mir-661 ; hsa-mir-196a-3p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-939-3p ; hsa-mir-6840-3p ; hsa-mir-6849-3p ; hsa-mir-4433a-3p ; hsa-mir-5000-3p ; hsa-mir-4436a ; hsa-mir-5000-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-3194-5p ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-605-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-940 ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-3714 ; hsa-mir-665 ; hsa-mir-8055 ; hsa-mir-6807-5p ; hsa-mir-4266 ; hsa-mir-6894-5p ; hsa-mir-7160-5p ; hsa-mir-3135a ; hsa-mir-4445-5p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-7162-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-766-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-759 ; hsa-mir-5586-3p ; hsa-mir-508-5p ; hsa-mir-4797-5p ; hsa-mir-6739-3p ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-7109-5p ; hsa-mir-4790-5p ; hsa-mir-6868-3p ; hsa-mir-3127-5p ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-593-3p ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-486-3p ; hsa-mir-6795-5p ; hsa-mir-3140-3p ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-4790-3p ; hsa-mir-6730-3p ; hsa-mir-4680-3p ; hsa-mir-5187-3p ; hsa-mir-4427 ; hsa-mir-4653-5p ; hsa-mir-3921 ; hsa-mir-301b-5p ; hsa-mir-301a-5p ; hsa-mir-4315 ; hsa-mir-146a-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6891-3p ; hsa-mir-6072 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-211-3p ; hsa-mir-4748 ; hsa-mir-329-5p ; hsa-mir-4464 ; hsa-mir-7845-5p ; hsa-mir-888-3p ; hsa-mir-4506 ; hsa-mir-651-5p ; hsa-mir-7977 ; hsa-mir-342-3p ; hsa-mir-383-3p ; hsa-mir-1228-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-498 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-562 ; hsa-mir-129-5p ; hsa-mir-3912-5p ; hsa-mir-4309 ; hsa-mir-3198 ; hsa-mir-6794-3p ; hsa-mir-6755-3p ; hsa-mir-198 ; hsa-mir-4294 ; hsa-mir-1289 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-1304-3p ; hsa-mir-4639-3p ; hsa-mir-6514-5p ; hsa-mir-3664-5p ; hsa-mir-4279 ; hsa-mir-887-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-890 ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4311 ; hsa-mir-26b-5p ; hsa-mir-34a-5p ; hsa-mir-155-3p ; hsa-mir-130b-3p ; hsa-mir-1296-5p ; hsa-mir-133a-3p ; hsa-mir-3622b-5p ; hsa-mir-22-3p ; hsa-mir-1200 ; hsa-mir-4324 ; hsa-mir-544b ; hsa-mir-6869-5p ; hsa-mir-1273g-3p ; hsa-mir-1292-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-7703

Nearest TSS

Nearest CpG islands

chr17-CpG: 119/Target, None/Upstream, None/Downstream

Nearby gene

PPP1R1B ; ZPBP2(+) ;

Nearest cancer related gene

ERBB2(OG, No orient, 0)

Upstream sequence

caagtcctcctgcctcagtctcccaaagtgctgggattacaagcatgacccatcacacccagccTAAAATACAGATTTCTTGTCACATAAGTGATTTCCA

Downstream sequence

CATAGATTTTCTTCTATAGACAACTGGTTTAGCCCAAAGCAGCTCAGCTTTTCACTGGAGATGGGAAGGTAAAGGACAGAAGCAGAAGTGCCATCAGATG

Target sequence

acccaggtgatgtaactcttgtgttggatctgcctatgggggcattgagacatatttctgcactgatcacccaggtgatgtaacacttgtgttggatctgcctataggggcattgtgacatatttctgcactgatcacccaggtgatgggactcttgtctaggctctgtgtatgggggctttctgacatatctctgcactgatcacccaggtgatgtaacgcttgactaggctctgcctacggggcacagtgaca