Basic Information
VIS ID
TVIS20005077
Fusion event
HPV-chr22:q13.31 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV31
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
46505183/46109303 (Hg38)
End
46521319/46125439 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
MIR4763 ; MIRLET7A3 ; MIRLET7B ; MIRLET7BHG
Nearest TSS
ENST00000624155/Upstream/23300; ENST00000460086/Downstream/25082;
Nearest CpG islands
chr22-CpG: 23/Target, None/Upstream, None/Downstream
Nearby gene
PRR34 ; PPARA(+) ;
Nearest cancer related gene
MIRLET7B(TSG, No orient, 0)
Upstream sequence
CTGGGTAAGGCCACGTCTCTTCCAGAGCTGACACTTGTCACTTTTGTTTTTAAAACCCAACAGGTCAAGAAGTGGCGCTGACCTGGAGCCCCTGCCTGGG
Downstream sequence
gcggggctttgggtcaaatgctcagccctgagccaatgactgaggGTTCCCACTGGAGGGGCAGTGGGAGAGACAGGGGACACCCAGTGGGTGGAGCCGG
Target sequence
GCTGGCCTTCCTCACAGTGAGCTGGGCCTCCTGCCATCCTGGCTCTGGAGGTAGGAGGAGCCGTGGGAGGTCTGATAGGGAGGGAGGGCTATCTCAGAGCCAGGCCACTCCCGGTCCTCTCCAGGCCCCACCCTCAGGCACAGAGGTCCTTAGGTGGGGACTTGATGGTCTCACAGCCAAACCTTCGCCCAGGCTGTGGCCTCCCCTGAAGCCATGTCTCTTCTTGTCTTCCCGCCACTCTTCCAGCAAGCTCCC
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate