Basic Information
VIS ID
TVIS20005078
Fusion event
HPV-DACH1 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
HQ644271.1
Host Sequence
Chromosome
chr13
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
72413228/71839096 (Hg38)
End
72462826/71888688 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA13B
Target gene
DACH1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-217
Nearest miRNA
hsa-mir-1297/Upstream/5620772; hsa-mir-1267/Downstream/5809324;
Nearest TSS
ENST00000623511/Upstream/823955; ENST00000618209/Downstream/838999;
Nearest CpG islands
chr13-CpG: 62/Target, None/Upstream, None/Downstream
Nearby gene
ATXN8OS ; MZT1(+) ;
Nearest cancer related gene
DACH1(TSG, No orient, 0)
Upstream sequence
tttatgtctgagtagtatcccatggtgtatttgtatgtatgcatacatcacacacacacacacacacacacacacacacatatatatataattttcttta
Downstream sequence
agtcctctgatcattgtcatttgtccaggggtgggcatggactttagtggtaccaaaaaaaatctcgcattcctatttgaaatgctgagacagaagtaca
Target sequence
TCCATTTAACTATGAATAATTCATAATGGAAAAATAATATTTGACCTCTGAGAATTATTAAGAATGCTTTTTTTCTTTTAAAAGTTAATATGTGGTTTTCAAAGTTACTTGAATCCAGAAGACAGAGAGAAAAAATCAGTGCTTTTAATATCATAAAGAAATTATTAAAATGTCAGTTCATACAGTAACTTTGAAATCCATCTAAAAACCTCATTCATTATTTTACGGTTAAAACTcacggtggctcacacctgt
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate