Basic Information
VIS ID
TVIS20005081
Fusion event
HPV-COA1 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
HQ644271.1
Host Sequence
Chromosome
chr7
Cytoband
p13
Reference genome
GRCh37/hg19
Start
43684947/43645348 (Hg38)
End
43810323/43770724 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7D
Target gene
COA1
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-17-5p ; hsa-mir-218-5p ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-6077 ; hsa-mir-6783-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-651-3p
Nearest miRNA
hsa-mir-1183/Upstream/494354; hsa-mir-10399/Downstream/281042;
Nearest TSS
ENST00000635602/Upstream/3184; ENST00000453612/Downstream/411;
Nearest CpG islands
chr7-CpG: 64/Target, None/Upstream, None/Downstream
Nearby gene
STK17A ; MRPS24(+) ;
Upstream sequence
ttgaatcctgacACACAGAAAAAGATTTACTTTTTAGAACTTAGAAAATATCCATAATCCAAGACAATTAAGCCAATTTAAAATATTAGTCTGGCATTTA
Downstream sequence
GCTAGGAAGAAAAAAAAGTACATATTTCTTATTGCCTTGCTTGTCCCCATTTAAAAAGCCAGATAAAAAACTGTCCTCTTCAAGCACCAGTTTTGGGAAG
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate