Basic Information
VIS ID
TVIS20005097
Fusion event
HPV-RAD51B integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Adenocarcinoma (AC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
HQ644271.1
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68596826/68130109 (Hg38)
End
68607359/68140642 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/688179; hsa-mir-1185-1/Downstream/4376178;
Nearest TSS
ENST00000550708/Upstream/129830; ENST00000554575/Downstream/246495;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/454944, chr14-CpG: 40/Downstream/487656
Nearby gene
ZFYVE26 ; ZFP36L1(+) ;
Upstream sequence
ataccttttcactttttacatggtcaagctgctaattttccaagtctttctgttccgcttaccatttaattataaattccatttttaaatcatttcttcc
Downstream sequence
CACTTTCAAGGTTCACTAATCAGAATTTACAGCATTTCTTTTGCAGTCCTCTTCATACCCCCTGCCATGCTCACAGAGTTAGGTCTGGTAGATTTCATAC
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate