Basic Information
VIS ID
TVIS20005104
Fusion event
HPV-PROX1 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
HQ644271.1
Host Sequence
Chromosome
chr1
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
214139309/213965966 (Hg38)
End
214198802/214025459 (Hg38)
Location type
Intronic
Target gene
PROX1
miRNAs that regulate target gene
hsa-mir-181a-5p ; hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-877-5p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-8070 ; hsa-mir-297 ; hsa-mir-4666a-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-4501 ; hsa-mir-2681-5p ; hsa-mir-377-3p ; hsa-mir-670-5p ; hsa-mir-489-3p ; hsa-mir-466 ; hsa-mir-198 ; hsa-mir-3973 ; hsa-mir-4432 ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-548u ; hsa-mir-6507-3p ; hsa-mir-7161-5p ; hsa-mir-888-5p ; hsa-mir-4787-3p ; hsa-mir-5589-3p ; hsa-mir-574-5p ; hsa-mir-675-3p
Nearest miRNA
hsa-mir-101-1/Upstream/1888281; hsa-mir-1182/Downstream/6092394;
Nearest TSS
ENST00000473358/Upstream/39312; ENST00000484459/Downstream/5442;
Nearest CpG islands
chr1-CpG: 42/Target, None/Upstream, None/Downstream
Nearby gene
RPS6KC1 ; SMYD2(+) ;
Nearest cancer related gene
PROX1(TSG, No orient, 0)
Upstream sequence
GGCTTTCTGGCTGTGGGCAGCTGAGAGGACAAAAGAAAGGAAGAAAAAAGGGAAAAGTAAACCACTGCCCCCCAGTTGAGCCAGGTTCCTCCTGGAGACC
Downstream sequence
aatgacttaaatttttaaacagttgtaaaaaataaggagaatatccaacctagaccaaatatggcccacagagcctatgtatttattacctggcccttta
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate