Basic Information
VIS ID
TVIS20005105
Fusion event
HPV-RAD51B integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV52
Reference genome
HQ537731.1
Host Sequence
Chromosome
chr14
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
68986041/68519324 (Hg38)
End
69029256/68562539 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA14C
Target gene
RAD51B
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-4668-5p ; hsa-mir-2053 ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-1273h-5p ; hsa-mir-569 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6871-5p ; hsa-mir-4496 ; hsa-mir-4506
Nearest miRNA
hsa-mir-208a/Upstream/1077394; hsa-mir-1185-1/Downstream/3954281;
Nearest TSS
ENST00000550708/Upstream/47291; ENST00000553944/Downstream/65906;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/844159, chr14-CpG: 40/Downstream/65759
Nearby gene
ZFYVE26 ; ZFP36L1(+) ;
Upstream sequence
tgagttttctattcaggctgaaatgaaatcaaggtattggttggcagtgttcttacctggagctcatagtcctcttccaagatcattccttttattggca
Downstream sequence
TTTGGCACGTGGCAAACTAACTCCTTTTGTGTACTGTGCAGTCTTAGGAGTAATGAGGCAGCAATATTATTGTTAGTTCTCTGTTCTAATGATCAGCTGT
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate