Basic Information
VIS ID
TVIS20005112
Fusion event
HPV-MACROD2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Adenosquamous carcinoma (ASC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
14954915/14974269 (Hg38)
End
14955301/14974655 (Hg38)
Location type
Intronic
Target gene
MACROD2
miRNAs that regulate target gene
hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4469 ; hsa-mir-486-5p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-618 ; hsa-mir-502-5p ; hsa-mir-4786-3p ; hsa-mir-1915-5p ; hsa-mir-6841-3p ; hsa-mir-153-5p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-486-3p ; hsa-mir-4252 ; hsa-mir-4725-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-504-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/4324574; hsa-mir-1-1/Downstream/3495960;
Nearest TSS
ENST00000382410/Upstream/38906; ENST00000486914/Downstream/222203;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/977847, chr20-CpG: 50/Downstream/1598536
Upstream sequence
CAGGTGGTAAAGCGGGGACCAGAGTCCAGATTCCACCCACCTTTGAGTTATGTGCTTCTTTCCCTGGGCCCGGGGAACATGCAGGGAATTCCTGATTTTT
Downstream sequence
GTAAAATGGACCACCTCAGGCAACCTTTCAGTAAAGGAGCAAAGGGAATACATACCTTGACTTTATTATTCTCTCCTACTGCAGTTTGCACTGCAAGTCC
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
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