Basic Information
VIS ID
TVIS20005113
Fusion event
HPV-FMO3 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Adenosquamous carcinoma (ASC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
171076978/171107837 (Hg38)
End
171086298/171117158 (Hg38)
Location type
Intronic
Target gene
FMO3
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/6031; hsa-mir-1182/Downstream/1021640;
Nearest TSS
ENST00000473358/Upstream/7075; ENST00000493513/Downstream/68050;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/442800, chr1-CpG: 56/Downstream/368220
Nearby gene
MROH9 ; FMO6P(+) ;
Upstream sequence
CACCGTTCTCCCTGCAAGGAGCCACCACCATCCAGTGAGGAGGGTCCCTTCCACCCAAGAGCTCAGACCACTGTGCAGGCCAGTGACGGCCTGGAGGGGC
Downstream sequence
CCTTCATTGGGGCAAAGCCCAACATCCCATGGCTGTTTCTCACAGATCCCAAATTGGCCATGGAAGTTTATTTTGGCCCTTGTAGTCCCTACCAGTTTAG
Target sequence
GTAAGGCCAAAATTTAAGCTGCTAGCCACATAACTGACAAAAATGAATATCTTGATAATGTCTTCTTTTTTCTAAAAGTATAAGCAGGTTAAATTAAAATATACTTCTGTTATATCTAATATGCTTGGTGTGTTAAAATAGCACATTATTGTGACTGCATCTATTCACAAGGTCGCTTCTGTTAAAGTCTTTGTTTAAATATATGACTCAAACTGCCATGTATTTCTCACTTTTCACTCAGGACTAAACCACTTT
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate