Basic Information
VIS ID
TVIS20005120
Fusion event
HPV-POC1B integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
HQ644271.1
Host Sequence
Chromosome
chr12
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
89814747/89420970 (Hg38)
End
89818872/89425095 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
POC1B
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-124-3p
Nearest miRNA
hsa-let-7i/Upstream/2675821; hsa-mir-1178/Downstream/5136694;
Nearest TSS
ENST00000382841/Upstream/49150; ENST00000605233/Downstream/4365;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/66603, chr12-CpG: 84/Downstream/100140
Nearby gene
DUSP6 ; ATP2B1(+) ;
Upstream sequence
TAGAAGAAATTTGAATAAGCTTAACCGTTGATTAGAAGtatggcagatgctacttgtcctccaaaagttattctctttttctataaaaagtgttagcttg
Downstream sequence
GTATCCAGAATTGTTTTGTGTATTTTACCCCCAAGTGCAACTCATGCAACCTGTGTCATGCCCACCTGTGTCAAAACATTGAGTTGTTCCATAATATGCT
Target sequence
TTTAAATTAGTCCTTAGGTATGCCTTTTCTGCCTTTTGTTCTGTTGCTCACCCTTTTAAGAAATGCCATGATAAATAGCACATGGTTGTGTTGTATGGAGTATCTTGTACTACCTTCCTGAGTGTATGTACATTTGTTCATTTATTGGGCCTCTGCCCAACAAATGAAAATGAATTTTTTATTCAGCTTTTCTGTTGGACAGCACTGAAAAGCTTTTGCTGATTTTCAAGGCAGTCTTTCAGCTTATCCTCTGTC
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
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