VISDB Viral Integration Site DataBase

VIS ID

TVIS20005121

Fusion event

HPV-CEACAM5 integration

Validated

Yes

Detection method

RNA-Seq+RT-PCR

Data source

Curated

Sample type

Disease

Adenocarcinoma (AC)

Quality evaluation

Good

Reported year

2014

PubMed ID

Virus name

HPV

Subtype

HPV16

Reference genome

Chromosome

chr19

Cytoband

q13.2

Reference genome

Start

End

42223935/41720016 (Hg38)

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-4279 ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-4783-5p ; hsa-mir-6778-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-764 ; hsa-mir-552-3p ; hsa-mir-582-3p

Nearest miRNA

hsa-mir-10395/Upstream/1341515; hsa-let-7e/Downstream/149611;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/67160, chr19-CpG: 51/Downstream/124596

Nearby gene

CEACAM7 ; CEACAM6(+) ;

Upstream sequence

gtaatcccagcactttgggaggctgagacgagcaggtcagaagttcaagaccagcctggccaacatggtgaaacctgtctctactaaaaataccaaaata

Downstream sequence

CTCAGAACACAACCTACCTGTGGTGGGTAAATGGTCAGAGCCTCCCAGTCAGTCCCAGGCTGCAGCTGTCCAATGGCAACAGGACCCTCACTCTATTCAA

Target sequence

GGGGAATGAGTGAAGGAATGATCCATAACCTCTATAGAGACTGGATCCTGGATGCAGAATCCTGGGAGGTTCTGACCACACCTGTTCCGTGTCCATCAGGGGCTGAGATCCATGTACCATTCCTCTGACCCCCTGTCCCGAAAGCCACCCTATCTCATGTGACTCTGGGGTTCCTTGGCCATGGGAGGGTTTTCAAGGCTCCCTGGTCCTGGTCGGGACAGCCAAGGGACTCCTAGTCCTGGGGTCTCCGAGGTC