Basic Information
VIS ID
TVIS20005125
Fusion event
HPV-chr8:q24.21 integration
Validated
Yes
Detection method
RNA-Seq+RT-PCR
Data source
Curated
Sample type
Tumor
Disease
Clear cell carcinoma (CCC)
Quality evaluation
Good
Reported year
2014
PubMed ID
24390348
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128195023/127182778 (Hg38)
End
128195511/127183266 (Hg38)
Location type
Intergenic
Fragile sites / regions
FRA8C ; FRA8E
Nearest miRNA
hsa-mir-12123/Upstream/2360720; hsa-mir-10400/Downstream/612696;
Nearest TSS
ENST00000518652/Upstream/102904; ENST00000642795/Downstream/61371;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/624253, chr8-CpG: 29/Downstream/132376
Nearby gene
LRATD2 ; MYC(+) ;
Nearest cancer related gene
MYC(OG, +) ;
Upstream sequence
ATTTGATTACATTTAATTTGAGAACAGAGTTGATACTTATTCTTCTTGATTAATTTATAGTCAATTAGAGAATTTTGCACTATATTGCATCTTGAACTTA
Downstream sequence
ctagaagaaaacccaggcaataccattcaggacacaggcatgggcagagacttcatgactaaagcatcaaaagcaatggcaacaaaagccaaaattgaca
Target sequence
ATGTATAAACAGGGGCAGAGcaaagtaatgtatagattcaatgctactcccatcaagctaacattgactttttttgcagcattagaaaaaaactactttaaatttcatctggaaccaaaaaagagcccatatagccaagacaatcctaagcaaaaagaacaaagctggaggcatcatactacctgacttcaaactatactacaaggctacagtaaccaaaacagcatggtactggtaccaaaacagatatataga
Reference
Ojesina, A. I., et al. Landscape of genomic alterations in cervical carcinomas. Nature,2014,506(7488): 371-375.
Curate