Basic Information
VIS ID
TVIS30000022
Fusion event
HIV-ZNF140 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
133679243/133102657 (Hg38)
End
133679243/133102657 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ZNF140
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-let-7i/Upstream/520596;
Nearest TSS
ENST00000382841/Upstream/21072; ENST00000606110/Downstream/13035;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/21430, chr12-CpG: 114/Downstream/27285
Upstream sequence
tctactaagatacataagtaaataaataaataaaataaaccattagccaggcgtggcagcgtgtgcctgtagtcccagctactcgggaggctgaggcagg
Downstream sequence
agaattgctcaaacctgggaggcggcggttgcagtgagccaagatcgtgccactggaccccagcctgggtgacagagcgagactccgtttcttaaaaaaa
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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