Basic Information
VIS ID
TVIS30000025
Fusion event
HIV-C2CD3 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73767645/74056600 (Hg38)
End
73767645/74056600 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
C2CD3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10392/Upstream/1273008; hsa-let-7a-2/Downstream/342637;
Nearest TSS
ENST00000527297/Upstream/7203; ENST00000542710/Downstream/14269;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/72843, chr11-CpG: 58/Downstream/114254
Upstream sequence
aaatgtcatctaatttggacctaacaatgaccttataaaaatgatccccactttacagatgaagaatctgtggctcagagatgttatgtaacttgatcac
Downstream sequence
acagtcagtaaattacagagatggagttggagaccaagtgtctctggttcaaatgcccagggtctttccactacaccaGAAGTCTTTTCCAAGGATGAAA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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