Basic Information
VIS ID
TVIS30000026
Fusion event
HIV-NSD3 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr8
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
38167585/38310067 (Hg38)
End
38167585/38310067 (Hg38)
Orient
+
Location type
Intronic
Target gene
NSD3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-155-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-10b-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-203a-3p ; hsa-mir-526b-5p ; hsa-mir-4635
Nearest miRNA
hsa-mir-124-1/Upstream/8352719; hsa-mir-10400/Downstream/2960981;
Nearest TSS
ENST00000518652/Upstream/10273; ENST00000527912/Downstream/9224;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/40553, chr8-CpG: 160/Downstream/71604
Nearest cancer related gene
NSD3(OG, No orient, 0)
Upstream sequence
GAAGTGTACCAAATAGGTACTAAACTAATTTTCATGTCATTAATTAAAAGCACTTAATttttttaataattgtggtaaaatatatataacataaaattta
Downstream sequence
acactttaaccatttttaagtgtacggttcagtagcattaagtacattcacattgttaccactgtctgcctccagaacattttcatcatcccatactgaa
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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