Basic Information
VIS ID
TVIS30000033
Fusion event
HIV-HAUS5 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
36111009/35620107 (Hg38)
End
36111009/35620107 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA19A
Target gene
HAUS5
miRNAs that regulate target gene
hsa-mir-6741-5p ; hsa-mir-6514-3p ; hsa-mir-7977 ; hsa-mir-6748-5p ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-876-3p ; hsa-mir-323a-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-6811-3p ; hsa-mir-541-3p ; hsa-mir-214-5p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-506-5p ; hsa-mir-892c-5p ; hsa-mir-4786-5p ; hsa-mir-3176 ; hsa-mir-3922-3p ; hsa-mir-3190-5p ; hsa-mir-4692 ; hsa-mir-622 ; hsa-mir-4514 ; hsa-mir-1288-5p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-3160-5p ; hsa-mir-8073 ; hsa-mir-221-5p
Nearest miRNA
hsa-mir-10395/Upstream/274480; hsa-let-7e/Downstream/3789516;
Nearest TSS
ENST00000633603/Upstream/49; ENST00000592526/Downstream/8923;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/7205, chr19-CpG: 40/Downstream/8890
Upstream sequence
GTAGGTTGAAGCCCCTGCCCACGGTCCTCCCATCCATCCACCAGCTGCACCCCGCGTCCCCAAGGGGCTCCAGCTTCATAGCGCTGAGCCACAAGCTGGG
Downstream sequence
GCTGCCTCCAGGGAAGGTGAGTGCCCGTCTCCTGTGACTTGTCTCCCCAGCCCCGCCCCAGGTGACCGTCCTTCCCTCCTCCTCCAGGCCTCGGAGCTGC
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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