Basic Information
VIS ID
TVIS30000034
Fusion event
HIV-STAT5B integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
40406513/42254495 (Hg38)
End
40406513/42254495 (Hg38)
Orient
+
Location type
Intronic
Target gene
STAT5B
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-1229-3p ; hsa-mir-93-3p ; hsa-mir-324-3p ; hsa-mir-134-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-335-3p ; hsa-mir-6734-5p ; hsa-mir-1226-5p ; hsa-mir-6834-5p ; hsa-mir-526b-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-423-5p ; hsa-mir-3184-5p ; hsa-mir-4762-5p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-106b-3p ; hsa-mir-150-5p ; hsa-mir-28-5p ; hsa-mir-182-3p ; hsa-mir-28-3p
Nearest miRNA
hsa-mir-1180/Upstream/737278; hsa-mir-10226/Downstream/240278;
Nearest TSS
ENST00000595228/Upstream/36624; ENST00000592536/Downstream/14092;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/69904, chr17-CpG: 126/Downstream/21438
Upstream sequence
CTGCTTTAAAGCTAAATTCCATAGATTACTTTTCAAATCATCCTTCGAAGCTGTCCTCTCTTTGTTCCTATCAGTCAGAACTCCCAGTATATTTCTCTTT
Downstream sequence
TTCCTCAACAAGTTAGTTTCTGTCCTTAAAAAAAAAAAAATTAAGAATATTTCCCCTTCATTTTGGTTCTCTTACTCTCTTTTTCTCTCTCCCTCCAGGT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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