Basic Information
VIS ID
TVIS30000037
Fusion event
HIV-ZC3H13 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr13
Cytoband
q14.13
Reference genome
GRCh37/hg19
Start
46537080/45962945 (Hg38)
End
46537080/45962945 (Hg38)
Orient
-
Location type
UTR3
Target gene
ZC3H13
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-374b-3p ; hsa-mir-6794-3p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-520f-5p ; hsa-mir-4509 ; hsa-mir-4744 ; hsa-mir-4639-3p ; hsa-mir-4698
Nearest miRNA
hsa-mir-2276/Upstream/1766745; hsa-mir-1267/Downstream/4033470;
Nearest TSS
ENST00000623511/Upstream/111209; ENST00000606351/Downstream/48610;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/248866, chr13-CpG: 51/Downstream/89374
Upstream sequence
CTCCCCATTAATAAAGTATTAGTAAGTTGCAAAATAAACTAAGGTAGGTACTAGATGAGACAGAGACAGTGAAAACCAAAACCAAACAACCCCTACCACC
Downstream sequence
AGAATCCATAAGCTAGATAATCTGGAATAACTGAAAATTGCTGCAGTGAGGTCAAAAATCAGCGTGATAGGATATTTTCAAagtagcagttaatatttat
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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