Basic Information
VIS ID
TVIS30000040
Fusion event
HIV-AIDA integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
222875793/222702451 (Hg38)
End
222875793/222702451 (Hg38)
Orient
+
Location type
Intronic
Target gene
AIDA
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-4460 ; hsa-mir-6828-5p ; hsa-mir-140-5p ; hsa-mir-6718-5p ; hsa-mir-203b-5p ; hsa-mir-6755-5p ; hsa-mir-4433b-3p ; hsa-mir-6510-5p ; hsa-mir-3121-3p ; hsa-mir-1208 ; hsa-mir-1304-3p ; hsa-mir-202-3p ; hsa-mir-329-5p ; hsa-mir-3653-3p ; hsa-mir-3665 ; hsa-mir-4477b ; hsa-mir-513b-5p ; hsa-mir-5197-3p ; hsa-mir-657 ; hsa-mir-6755-3p ; hsa-mir-6760-3p ; hsa-mir-7856-5p
Nearest miRNA
hsa-mir-101-1/Upstream/2501832; hsa-mir-1182/Downstream/1554589;
Nearest TSS
ENST00000473358/Upstream/26233; ENST00000496267/Downstream/9812;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/58122, chr1-CpG: 70/Downstream/9533
Upstream sequence
TAAGAGATGGGGAATAGACTGACACTTTTTTTTTCATTATCTACAAGATTAAACATTGACTTAACACTAGATACTCTGAGCCAAGAGATAATGGGAGTTG
Downstream sequence
TTTCCTCCCATTCCTTCTAACTCTTTTAAAGCTTCAGTCGCCCATTTTTCATAATCACTAACAGTTTAGAAACTCAACTTGACACACAAAAAATTTAATT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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