Basic Information
VIS ID
TVIS30000043
Fusion event
HIV-GNPDA2 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr4
Cytoband
p12
Reference genome
GRCh37/hg19
Start
44720750/44718733 (Hg38)
End
44720750/44718733 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNPDA2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-106b-5p ; hsa-mir-122-5p ; hsa-mir-374a-5p
Nearest miRNA
hsa-mir-12113/Upstream/4216614; hsa-mir-1243/Downstream/2933936;
Nearest TSS
ENST00000502981/Upstream/7710; ENST00000515623/Downstream/7790;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/40009, chr4-CpG: 64/Downstream/7283
Upstream sequence
TGGAAAATTATCCTTGAGTTGTTGGGTACTGGGATATACTATAACAAATTCTAAGATTAGAAGCTTCTAGAATATATAACTGACTTTTTAAAAATCTCCC
Downstream sequence
TTTCTGAAAAAAAAATCTTGAGTTCTTGCACAAATGATATGTAAATAGGTCAAGTGTTGACCATTTACTGAAATTAAAAGGGAAAACAGGGCTAAATTTA
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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