Basic Information
VIS ID
TVIS30000044
Fusion event
HIV-FAM168A integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73256917/73545872 (Hg38)
End
73256917/73545872 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
FAM168A
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-10a-5p ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-555 ; hsa-mir-765 ; hsa-mir-5702 ; hsa-mir-6861-5p ; hsa-mir-6742-3p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-331-3p ; hsa-mir-3139 ; hsa-mir-708-5p ; hsa-mir-28-5p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-6801-5p ; hsa-mir-4266 ; hsa-mir-766-5p ; hsa-mir-3202 ; hsa-mir-3179 ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-6825-5p ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-4722-5p ; hsa-mir-6731-5p ; hsa-mir-1827 ; hsa-mir-4768-3p ; hsa-mir-4259 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-6888-5p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-10392/Upstream/762280; hsa-let-7a-2/Downstream/853365;
Nearest TSS
ENST00000527297/Upstream/77380; ENST00000536527/Downstream/52225;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/168635, chr11-CpG: 63/Downstream/51882
Upstream sequence
tcctgggctcaagtggtccacttgccccagcctcccaaagtgttgggattacaggcataagccacggcgcccagccaaCATACTCTttattttacttaat
Downstream sequence
attcacaacaaaaaaaccctgtgagatgagggttagcaattcacccatcttgcagacaaaacacctacatctcacagaaattaaaagatttaaggttttt
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate