Basic Information
VIS ID
TVIS30000048
Fusion event
HIV-GNA13 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
63049842/65053724 (Hg38)
End
63049842/65053724 (Hg38)
Orient
+
Location type
Exonic
Target gene
GNA13
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-30b-5p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-18a-3p ; hsa-mir-100-5p ; hsa-mir-138-1-3p ; hsa-mir-3134 ; hsa-mir-8082 ; hsa-mir-4534 ; hsa-mir-3924 ; hsa-mir-570-3p ; hsa-mir-380-3p ; hsa-mir-4495 ; hsa-mir-411-3p ; hsa-mir-379-3p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-6715b-3p ; hsa-mir-3145-3p ; hsa-mir-3614-3p ; hsa-mir-141-3p ; hsa-mir-200a-3p ; hsa-mir-494-5p ; hsa-mir-410-5p ; hsa-mir-323b-5p ; hsa-mir-548g-3p ; hsa-mir-548av-3p ; hsa-mir-29b-1-5p ; hsa-mir-5571-5p ; hsa-mir-31-5p
Nearest miRNA
hsa-mir-10226/Upstream/231622; hsa-mir-1250/Downstream/1733348;
Nearest TSS
ENST00000595228/Upstream/1815; ENST00000582940/Downstream/2050;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/77549, chr17-CpG: 122/Downstream/2051
Nearest cancer related gene
GNA13(OG, No orient, 0)
Upstream sequence
GGCCCGGGTATCAAACGACATCATCTTATCTCCATGTTGTTGGTTTGAGTTGTCTCCCCAGGGAATATGAAGCTTCTCTCGAGCATCAACCAGCACCCTC
Downstream sequence
ATACCTTTGTTTAAAAAGAAGAAAAAAAATGTATGGAGAGGAGTCATTACATATTATCATAAGTTTTTATTCCAGTATTATTTCCTTATACTTCTGAATT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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