Basic Information
VIS ID
TVIS30000049
Fusion event
HIV-GPCPD1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
5565445/5584799 (Hg38)
End
5565445/5584799 (Hg38)
Orient
+
Location type
Intronic
Target gene
GPCPD1
miRNAs that regulate target gene
hsa-mir-769-5p ; hsa-mir-203a-3p ; hsa-mir-510-3p ; hsa-mir-552-5p ; hsa-mir-302c-5p ; hsa-mir-7848-3p ; hsa-mir-3143 ; hsa-mir-1184 ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-590-3p ; hsa-mir-543 ; hsa-mir-10b-5p ; hsa-mir-504-5p ; hsa-mir-10a-5p ; hsa-mir-103a-3p ; hsa-mir-107
Nearest miRNA
hsa-mir-103a-2/Upstream/1667228; hsa-mir-1-1/Downstream/1786809;
Nearest TSS
ENST00000382410/Upstream/9291; ENST00000378979/Downstream/1238;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/267647, chr20-CpG: 69/Downstream/25814
Upstream sequence
GCTTATTCTTATGTAGTGCATATTCTGAACTTGTCTCAAATGTAATTCTCCTCATATCCCAACTATTCACTACTGCCAGTTAAAAGCTTTACGAACAGCG
Downstream sequence
TGAACTTACCTGTATGTACAGAGCTGTGAGGAACTACCAAAAGAATAAACGCTAGCACAACCCCTTCTCCTAACAGAAATTTCAACTCAATGAGAAAAGC
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate