Basic Information
VIS ID
TVIS30000051
Fusion event
HIV-MRPL42 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
93895084/93501308 (Hg38)
End
93895084/93501308 (Hg38)
Orient
+
Location type
UTR3
Target gene
MRPL42
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-101-3p ; hsa-mir-186-5p
Nearest miRNA
hsa-let-7i/Upstream/6756159; hsa-mir-1178/Downstream/1060481;
Nearest TSS
ENST00000382841/Upstream/561; ENST00000547229/Downstream/68506;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/33545, chr12-CpG: 297/Downstream/68879
Upstream sequence
AAAAGACAGATGATGCGGAGGTTCCTGGGGGAATCAAAGAGAAATGTGCCTCATTTGCCATTTGAGAAAATGCAGTCTGGTGTATTCAGTAATATATAGT
Downstream sequence
AAAGTAATAATGATAAAATATCTTTTCATATATTAGAATGTGTACTTTTATATAAAGTAATTCTGGATTTGACATTCTCATTTAGAGAAACCTATTTTCT
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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