Basic Information
VIS ID
TVIS30000052
Fusion event
HIV-KSR1 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr17
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
25809620/27482594 (Hg38)
End
25809620/27482594 (Hg38)
Orient
-
Location type
Intronic
Target gene
KSR1
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-mir-218-5p ; hsa-mir-4286 ; hsa-mir-140-3p ; hsa-mir-548e-5p
Nearest miRNA
hsa-mir-1180/Upstream/188598; hsa-mir-10226/Downstream/878060;
Nearest TSS
ENST00000595228/Upstream/10581; ENST00000398985/Downstream/77723;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/25262, chr17-CpG: 20/Downstream/122877
Upstream sequence
GGACCAACTATGATTTAAAAATAATTTGGCCCCaggatgttaattgcagcattattttatactgatgacgaattacaaatcacctaaatatccaGTATCC
Downstream sequence
TATACCTACAACCTTGGGATAGTGTGTAAGTAAAAGTAAAACTGGAGCACATTTAGACCTATGGCACttaaaaacagcaaacatttgctataaagaatta
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
Curate