Basic Information
VIS ID
TVIS30000063
Fusion event
HIV-ARF3 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
49348335/48954552 (Hg38)
End
49348335/48954552 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
ARF3
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-320a ; hsa-mir-125b-5p ; hsa-mir-10a-5p ; hsa-mir-30c-5p ; hsa-mir-6834-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-34c-3p ; hsa-mir-6760-5p ; hsa-mir-5195-5p ; hsa-mir-582-3p ; hsa-mir-183-5p ; hsa-mir-377-3p ; hsa-mir-3941 ; hsa-mir-342-3p ; hsa-mir-4650-5p ; hsa-mir-6768-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-4789-5p ; hsa-mir-4477a ; hsa-mir-4424 ; hsa-mir-6770-5p ; hsa-mir-3976 ; hsa-mir-3123 ; hsa-mir-3925-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/182515; hsa-let-7i/Downstream/1279590;
Nearest TSS
ENST00000382841/Upstream/14889; ENST00000613114/Downstream/1888;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/29045, chr12-CpG: 52/Downstream/2504
Upstream sequence
atttggtacttactatatgctttgtacaataccaggtgctttacatttatctcatttaattctactgacaaccaaaaaaataataattctcttgaaaacc
Downstream sequence
atatgtcattaccttctttacagatgaagaaaataaagagagaagacaagcaattttacaagaaacatgcaactggtaattagcagaagcaggatttgaa
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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