Basic Information
VIS ID
TVIS30000068
Fusion event
HIV-SMAP2 integration
Validated
Yes
Detection method
dd-PCR+WGA
Data source
download(RID)
Sample type
PBMC
Disease
HIV-infected disease (HID)
Quality evaluation
Normal
Reported year
2019
PubMed ID
30688658
Virus Sequence
Virus name
HIV
Reference genome
K03455.1
Host Sequence
Chromosome
chr1
Cytoband
p34.2
Reference genome
GRCh37/hg19
Start
40845861/40380189 (Hg38)
End
40845861/40380189 (Hg38)
Orient
+
Location type
Intronic
Target gene
SMAP2
miRNAs that regulate target gene
hsa-mir-708-5p ; hsa-mir-652-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-25-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-12136/Upstream/2290860; hsa-mir-101-1/Downstream/374166;
Nearest TSS
ENST00000473358/Upstream/5541; ENST00000487871/Downstream/13156;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/5839, chr1-CpG: 53/Downstream/69744
Upstream sequence
ATTATTTACTTTTACCATTGCTAATCATAAATTTTTTAATCTTGATTTTATTAGTTTTACTTTTGACTTTATTCCCTTTTAAGATAGTCTGGTTACTGGG
Downstream sequence
AGCCACAGTTAGAATGACTCACCCAGTAATTCCCTAGTCTTTAAGCCAAAACCATTTCCTATATATGGAGTTCTGGCATTTTTGCAAATGTGCTTTATGG
Reference
Einkauf, K. B., et al. Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy. J Clin Invest,2019, 129(3): 988-998.
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